Camcorder footage captures two girls—one Israeli, one American—in corsets and bunny ears, high on coke, backstage at a Tokyo strip club. Yael films Melissa giggling, sobbing, heartbreakingly candid. Seven years later, Yael flies to the United States to find her friend again. Melissa, Mom & Me witnesses the emotional reunion of two strong women and charts the dramatically divergent paths their lives have taken.